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    SR-121463A 185913-79-5
    时间:2019-03-28 21:14:02 来源:
SR-121463A  185913-79-5
  • 价格:8600.00元/公斤
  • 分类:化工中间体
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青蛙appapp无限观看SR-121463A  185913-79-5


价格:8600元/公斤 含量:99% 包装:25公斤

青蛙appapp无限观看CAS;185913-79-5

分子式:C17H22ClNO3

青蛙appapp无限观看分子量:323.8228

化学名称 N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro[cyclohexane-1,3'-indolin]-1青蛙appapp无限观看'-ylsulfonyl]-3-methoxybenzamide fumarate

The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives 3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in THF to yield the disulfonate (III). The condensation of (III) with 5-ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V), which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the 2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the adduct (XII). Finally, the target compound is obtained by condensation of (XII) with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric acid.


青蛙appapp无限观看16359-54-9    C12H17ClN2       185913-79-5   C17H22ClNO3

402856-42-2   C17H23Cl2NO      65527-62-0    C21H27N3O

8378-23-2     C12H17NO         1099-87-2     C19H27NaO5S

青蛙appapp无限观看99918-43-1    C11H18Cl2N2      1445566-01-7  C13H17NO

6740-85-8     C12H13ClO        1445583-20-9  C18H26N4O2

14461-91-7    C12H12N2O2       612526-40-6   C17H12BrFN4

青蛙appapp无限观看39243-02-2    C16H12BrN5       40054-69-1    C17H15ClN4S

5650-44-2     C10H13NO         39742-60-4    C13H17NO

青蛙appapp无限观看13956-29-1    C21H30O2         4021-34-5     C17H26N2O

青蛙appapp无限观看2426-63-3     C17H27ClN2O      1364933-55-0  C23H22N2O

2894-68-0     C16H12Cl2N2O     39243-02-2    C16H12BrN5

青蛙appapp无限观看67579-76-4    C18H26Cl2N2O     33643-46-8    C13H16ClNO

77872-41-4    C13H18N2O        28910-91-0    C17H12ClFN4 

141-78-6      C4H8O2           87-90-1       C3Cl3N3O3

青蛙appapp无限观看13415-55-9    C18H22O2         5485-65-4     C15H22ClNO

776994-64-0   C17H23NO3        21409-26-7    C19H24N2

青蛙appapp无限观看13415-59-3    C16H24ClNO       2687-91-4     C6H11NO

青蛙appapp无限观看79-41-4       C4H6O2           23022-83-5    C9H9BrO

2114-00-3     C9H9BrO          49656-78-2    C10H14ClNO

936-59-4      C9H9ClO          93-55-0       C9H10O


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